Computational evaluation of small molecule inhibitors of RGS4 to regulate the dopaminergic control of striatal LTD
نویسندگان
چکیده
bbreviations: RGS, Regulator rs compacta; mGluR, meta ini Spinny Neurons; LTD, L binoid; AMP, Adenosine Mo ; L-VGCCs, L-type voltage-g ide; PLD, phospholipase D arachidonoylglycerol; HADD in-protein DOCKing; CPOR esidues in Transient complex terface Residues in Transien otein-protein interaction inh ILES, Simplified molecular Corresponding author at: Hu izza 52, I-10126 Torino, Italy mail address: riturajpurohit@ er review under responsibilit
منابع مشابه
RGS4 Is Required for Dopaminergic Control of Striatal LTD and Susceptibility to Parkinsonian Motor Deficits
Plasticity of excitatory synapses onto striatal projection neurons (MSNs) has the potential to regulate motor function by setting the gain on signals driving both direct- and indirect-pathway basal ganglia circuits. Endocannabinoid-dependent long-term depression (eCB-LTD) is the best characterized form of striatal plasticity, but the mechanisms governing its normal regulation and pathological d...
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